Cambodia is grappling with a significant resurgence of human H5N1 avian influenza cases, reporting 16 infections in 2025, including six fatalities. The majority of these cases involve children under 18, with exposure to sick or deceased poultry being the common link. Genetic analyses indicate that the virus strains belong to clade 2.3.2.1e, which has been circulating in the region for years. Despite the alarming rise in cases, the World Health Organization assesses the risk to the general population as low, as no human-to-human transmission has been reported.